Molecular evolution analysis of the human immunodeficiency virus type 1 envelope in simian/human immunodeficiency virus-infected macaques: implications for challenge dose selection.

@article{Varela2011MolecularEA,
  title={Molecular evolution analysis of the human immunodeficiency virus type 1 envelope in simian/human immunodeficiency virus-infected macaques: implications for challenge dose selection.},
  author={Mariana Varela and Lisa Landskron and Rachel Pei-Jen Lai and Trevelyan J. McKinley and Willy M. J. M. Bogers and Ernst J. Verschoor and Rob Dubbes and S Wienand Barnett and Simon D. W. Frost and Jonathan Luke Heeney},
  journal={Journal of virology},
  year={2011},
  volume={85 19},
  pages={10332-45}
}
Since the demonstration that almost 80% of human immunodeficiency virus type 1 (HIV-1) infections result from the transmission of a single variant from the donor, biological features similar to those of HIV mucosal transmission have been reported for macaques inoculated with simian immunodeficiency virus (SIV). Here we describe the early diversification events and the impact of challenge doses on viral kinetics and on the number of variants transmitted in macaques infected with the chimeric… CONTINUE READING