Molecular evidence that cortical synaptic growth predominates during the first decade of life in humans.

Abstract

Theories concerning the pathology of human neurodevelopmental disorders that emerge in adolescence, such as schizophrenia, often hypothesize that there may be a failure of normal cortical synaptic loss or pruning. However, direct evidence that synaptic regression is a major developmental event in the adolescent human cortex is limited. Furthermore… (More)
DOI: 10.1016/j.ijdevneu.2010.09.006

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