Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel.

@article{Du2013MolecularEF,
  title={Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel.},
  author={Yuzhe Du and Yoshiko Nomura and Gul Satar and Zhaonong Hu and Ralf Nauen and Sheng Yang He and Boris S. Zhorov and Ke Dong},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 29},
  pages={11785-90}
}
Pyrethroid insecticides are widely used as one of the most effective control measures in the global fight against agricultural arthropod pests and mosquito-borne diseases, including malaria and dengue. They exert toxic effects by altering the function of voltage-gated sodium channels, which are essential for proper electrical signaling in the nervous system. A major threat to the sustained use of pyrethroids for vector control is the emergence of mosquito resistance to pyrethroids worldwide… CONTINUE READING

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