Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel.

  title={Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel.},
  author={Yuzhe Du and Yoshiko Nomura and Gul Satar and Zhaonong Hu and Ralf Nauen and Sheng Yang He and Boris S. Zhorov and Ke Dong},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 29},
Pyrethroid insecticides are widely used as one of the most effective control measures in the global fight against agricultural arthropod pests and mosquito-borne diseases, including malaria and dengue. They exert toxic effects by altering the function of voltage-gated sodium channels, which are essential for proper electrical signaling in the nervous system. A major threat to the sustained use of pyrethroids for vector control is the emergence of mosquito resistance to pyrethroids worldwide… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 55 extracted citations


Publications referenced by this paper.
Showing 1-10 of 49 references

Activation of Drosophila Sodium Channels Promotes Modification by Deltamethrin

The Journal of general physiology • 2000
View 6 Excerpts
Highly Influenced

Jewess P (2005) Pyrethroids

BP Khambay
Comprehensive Molecular Insect Science, • 2005
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…