Molecular evidence for an ancient duplication of the entire yeast genome

  title={Molecular evidence for an ancient duplication of the entire yeast genome},
  author={K. Wolfe and D. Shields},
  • K. Wolfe, D. Shields
  • Published 1997
  • Biology, Medicine
  • Nature
  • Gene duplication is an important source of evolutionary novelty,. Most duplications are of just a single gene, but Ohno proposed that whole-genome duplication (polyploidy) is an important evolutionary mechanism. Many duplicate genes have been found in Saccharomyces cerevisiae, and these often seem to be phenotypically redundant. Here we show that the arrangement of duplicated genes in the S. cerevisiae genome is consistent with Ohno's hypothesis. We propose a model in which this species is a… CONTINUE READING

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