Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.

@article{Melo2013MolecularEF,
  title={Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.},
  author={Zesergio Melo and Silvia Cruz-Rangel and Roc{\'i}o Bautista and Norma V{\'a}zquez and Mar{\'i}a Casta{\~n}eda-Bueno and David B. Mount and Herminia Pasantes-Morales and Adriana Mercado and Gerardo Gamba},
  journal={American journal of physiology. Renal physiology},
  year={2013},
  volume={305 10},
  pages={F1402-11}
}
K(+)-Cl(-) cotransporter (KCC) isoforms 3 (KCC3) and 4 (KCC4) are expressed at the basolateral membrane of proximal convoluted tubule cells, and KCC4 is present in the basolateral membrane of the thick ascending loop of Henle's limb and α-intercalated cells of the collecting duct. Little is known, however, about the physiological roles of these transporters in the kidney. We evaluated KCC3 and KCC4 mRNA and protein expression levels and intrarenal distribution in male Wistar rats or C57 mice… CONTINUE READING