Molecular events underlying schistosomiasis-related bladder cancer.

  title={Molecular events underlying schistosomiasis-related bladder cancer.},
  author={N Ramchurren and Kumarasen Cooper and Ian C. Summerhayes},
  journal={International journal of cancer},
  volume={62 3},
Twenty-one invasive squamous-cell carcinomas (SCC) of the bladder from Schistosoma-hematobium-infected patients were examined immunohistochemically for the expression of p53, Rb, EGFR and c-erbB-2 proteins; and screened by single-strand conformation polymorphism and sequencing for mutations in the ras (H, N, K) codon hotspots (12, 13, 61) and p53 (exons 4-9) genes. Positive staining for p53, EGFR and c-erbB-2 was reported in 38, 67 and 28% of tumors respectively. Only one of the tumors, the… CONTINUE READING