Molecular epizootiology of genotoxic events in marine fish: linking contaminant exposure, DNA damage, and tissue-level alterations.

@article{Reichert1998MolecularEO,
  title={Molecular epizootiology of genotoxic events in marine fish: linking contaminant exposure, DNA damage, and tissue-level alterations.},
  author={William L. Reichert and M. S. Kristin Myers and Karen A. Peck-Miller and Benjamin French and Bernadita F. Anulacion and Tracy K. Collier and John Ellsworth Stein and Usha Varanasi},
  journal={Mutation research},
  year={1998},
  volume={411 3},
  pages={215-25}
}
Molecular epizootiological studies are increasingly being used to investigate environmental effects of genotoxic contaminants. The assessment of damage to DNA and linking the damage to subsequent molecular, cellular, or tissue-level alterations is a central component of such studies. Our research has focused on the refinement of the 32P-postlabeling assay for measuring covalent DNA-xenobiotic adducts arising from exposure to polycyclic aromatic compounds, using DNA adducts as molecular… CONTINUE READING
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