Molecular epidemiology of hepatitis B virus genotypes circulating in acute hepatitis B patients in the Campania region.

@article{Sagnelli2014MolecularEO,
  title={Molecular epidemiology of hepatitis B virus genotypes circulating in acute hepatitis B patients in the Campania region.},
  author={Caterina Sagnelli and Massimo Ciccozzi and Mariantonietta Pisaturo and Gianguglielmo Zehender and Alessandra Lo Presti and Loredana Alessio and Mario Starace and D. Lovero and Evangelista Sagnelli and Nicola Coppola},
  journal={Journal of medical virology},
  year={2014},
  volume={86 10},
  pages={1683-93}
}
Fifty-three HBV-DNA-positive patients with symptomatic acute hepatitis B were enrolled from 1999 to 2010 to evaluate molecular and phylogenetic changes in HBV in southern Italy. HBV polymerase region was evaluated by direct sequencing in plasma samples obtained at first observation. Different data sets were aligned and a phylogenetic tree was inferred using PhyML program. Statistical robustness was confirmed with a bootstrap analysis. A Bayesian Markov chain Monte Carlo method and a Bayesian… CONTINUE READING
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