Molecular epidemiology and evolution of resistance to quinolones in Escherichia coli after prolonged administration of ciprofloxacin in patients with prostatitis.

@article{Horcajada2002MolecularEA,
  title={Molecular epidemiology and evolution of resistance to quinolones in Escherichia coli after prolonged administration of ciprofloxacin in patients with prostatitis.},
  author={Juan Pablo Horcajada and Jordi Vil{\`a} and Antonio Moreno-Mart{\'i}nez and Joaquim Ruiz and Jos{\'e} Antonio Mart{\'i}nez and Miquel S{\'a}nchez and Eladio Soriano and Josep Maria Mensa},
  journal={The Journal of antimicrobial chemotherapy},
  year={2002},
  volume={49 1},
  pages={55-9}
}
The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied. In 11 of 23 patients, from whom only quinolone-susceptible E. coli was isolated before treatment, quinolone-resistant strains, genetically distinct from the quinolone-susceptible ones, predominated during and just after therapy. Two months after treatment, these were completely displaced by quinolone-susceptible E. coli… CONTINUE READING

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