Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function.

@article{Jin2008MolecularEO,
  title={Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function.},
  author={Ai-Hua Jin and Norelle L Daly and Simon T. Nevin and Ching-I. A. Wang and S{\'e}bastien Dutertre and Richard James Lewis and David J Adams and David J. Craik and Paul F Alewood},
  journal={Journal of medicinal chemistry},
  year={2008},
  volume={51 18},
  pages={
          5575-84
        }
}
Alpha-conotoxins are competitive antagonists of nicotinic acetylcholine receptors (nAChRs). The majority of currently characterized alpha-conotoxins have a 4/7 loop size, and the major features of neuronal alpha-conotoxins include a globular disulfide connectivity and a helical structure centered around the third of their four cysteine residues. In this study, a novel "molecular pruning" approach was undertaken to define the relationship between loop size, structure, and function of alpha… CONTINUE READING
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