Molecular engineering approaches to peptide, polyketide and other antibiotics

@article{Baltz2006MolecularEA,
  title={Molecular engineering approaches to peptide, polyketide and other antibiotics},
  author={Richard H. Baltz},
  journal={Nature Biotechnology},
  year={2006},
  volume={24},
  pages={1533-1540}
}
  • R. H. Baltz
  • Published 1 December 2006
  • Biology, Chemistry, Engineering
  • Nature Biotechnology
Molecular engineering approaches to producing new antibiotics have been in development for about 25 years. Advances in cloning and analysis of antibiotic gene clusters, engineering biosynthetic pathways in Escherichia coli, transfer of engineered pathways from E. coli into Streptomyces expression hosts, and stable maintenance and expression of cloned genes have streamlined the process in recent years. Advances in understanding mechanisms and substrate specificities during assembly by polyketide… 

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Polyketide Biosynthesis: Modular Polyketide Synthases

This review provides new perspectives on important biosynthetic mechanisms that contribute to the introduction of unique chemical functionality into these fascinating systems of polyketides.
...

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