Molecular electroporation: a unifying concept for the description of membrane pore formation by antibacterial peptides, exemplified with NK-lysin.

Abstract

The antibacterial activity of many small, positively charged peptides and proteins is based on pore formation in lipid bilayers. It is here proposed to arise from an electroporation effect. This hypothesis is supported by calculations of the electrostatic potential of NK-lysin associated to a membrane. For a significant area of the protein-membrane… (More)

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@article{Miteva1999MolecularEA, title={Molecular electroporation: a unifying concept for the description of membrane pore formation by antibacterial peptides, exemplified with NK-lysin.}, author={Meda Miteva and Mikael Andersson and Andrey Karshikoff and Gundula Otting}, journal={FEBS letters}, year={1999}, volume={462 1-2}, pages={155-8} }