Molecular effects of sulphonylurea agents in circulating lymphocytes of patients with non-insulin-dependent diabetes mellitus.

@article{Rabbone1998MolecularEO,
  title={Molecular effects of sulphonylurea agents in circulating lymphocytes of patients with non-insulin-dependent diabetes mellitus.},
  author={Ivana Rabbone and Marco Piccinini and Maria Curto and Michael J Mostert and Silvia Gamba and Silvia Mioletti and Robert Bruno and M. T. Rinaudo},
  journal={British journal of clinical pharmacology},
  year={1998},
  volume={45 3},
  pages={291-9}
}
AIMS In circulating lymphocytes of NIDDM patients pyruvate dehydrogenase (PDH), the major determinant in glucose consumption through oxidative pathways, is poorly active. The aim of this study is to examine whether sulphonylurea drug treatment revives PDH activity in circulating lymphocytes from NIDDM patients. METHODS Twenty normal-weight individuals with NIDDM were enrolled in this study. They had maintained their glycaemic levels close to normal by means of a restricted diet that had no… CONTINUE READING