Molecular effects of dopamine on striatal-projection pathways

@article{Gerfen2000MolecularEO,
  title={Molecular effects of dopamine on striatal-projection pathways},
  author={C. Gerfen},
  journal={Trends in Neurosciences},
  year={2000},
  volume={23},
  pages={s64-s70}
}
  • C. Gerfen
  • Published 2000
  • Biology, Medicine
  • Trends in Neurosciences
    • Gene regulation studies demonstrate that dopamine differentially regulates the direct and indirect projection neurons of the striatum through their respective expression of the D1 and D2 dopamine receptors. Induction of immediate-early genes (IEGs) in striatal neurons is used to study dopamine-receptor-mediated neuronal plasticity. In the dopamine-depleted striatum there is a switch in receptor-mediated signal transduction mechanisms to produce a supersensitive form of D1- mediated neuronal… CONTINUE READING
    View on Elsevier
    doi.org
    318 Citations
    Highly Influential Citations
    22
    Background Citations
    163
    Methods Citations
    4
    Results Citations
    7
    318 Citations
    Citation Type

    Citation Type

    Molecular substrates of action control in cortico-striatal circuits
    • 94
    • PDF
    Chapter IV Structural and functional interactions in the striatum at the receptor level
    • 22
    Brain dopamine receptors--research perspectives and potential sites of regulation.
    • 21
    • PDF
    Integrating neurotransmission in striatal medium spiny neurons.
    • J. Girault
    • Biology, Medicine
    • Advances in experimental medicine and biology
    • 2012
    • 74
    A model of dopamine modulated glutamatergic synapse
    • 7
    A Kinetic Model of Dopamine- and Calcium-Dependent Striatal Synaptic Plasticity
    • 76
    • PDF
    Kappa-Opioid Receptor Signaling in the Striatum as a Potential Modulator of Dopamine Transmission in Cocaine Dependence
    • 21
    • PDF
    WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine
    • 4
    • PDF
    The Physiology, Signaling, and Pharmacology of Dopamine Receptors
    • 1,754
    • PDF
    Striatal Plasticity and Basal Ganglia Circuit Function
    • 696
    • PDF

    References

    SHOWING 1-10 OF 53 REFERENCES
    A Complex Program of Striatal Gene Expression Induced by Dopaminergic Stimulation
    • 327
    • PDF
    Striatal Fos expression is indicative of dopamine D1/D2 synergism and receptor supersensitivity.
    • 184
    • PDF
    D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons.
    • 2,726
    Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior
    • 350
    Dynorphin opioid inhibition of cocaine‐induced, D1 dopamine receptor‐mediated immediatem‐early gene expression in the striatum
    • 97
    Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors.
    • 489
    • PDF
    Dynorphin regulates D1 dopamine receptor‐mediated responses in the striatum: Relative contributions of pre‐ and postsynaptic mechanisms in dorsal and ventral striatum demonstrated by altered immediate‐early gene induction
    • 82
    D1 dopamine receptor‐mediated induction of zif268 and c‐fos in the dopamine‐depleted striatum: Differential regulation and independence from NMDA receptors
    • 70
    6-Hydroxydopamine lesions of rat substantia nigra up-regulate dopamine-induced phosphorylation of the cAMP-response element-binding protein in striatal neurons.
    • 73
    • PDF
    Amphetamine and Dopamine-Induced Immediate Early Gene Expression in Striatal Neurons Depends on Postsynaptic NMDA Receptors and Calcium
    • 298
    • PDF