Molecular dynamics study of talin-vinculin binding.

  title={Molecular dynamics study of talin-vinculin binding.},
  author={Sunwoong Lee and Surasuk Chunsrivirot and Roger D Kamm and Mohammad R. K. Mofrad},
  journal={Biophysical journal},
  volume={95 4},
Cells can sense mechanical force in regulating focal adhesion assembly. One vivid example is the force-induced recruitment of vinculin to reinforce initial contacts between a cell and the extracellular matrix. Crystal structures of the unbound proteins and bound complex between the vinculin head subdomain (Vh1) and the talin vinculin binding site 1 (VBS1) indicate that vinculin undergoes a conformational change upon binding to talin. However, the molecular basis for this event and the precise… CONTINUE READING


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