Molecular dynamics simulations reveal the protective role of cholesterol in β-amyloid protein-induced membrane disruptions in neuronal membrane mimics.

@article{Qiu2011MolecularDS,
  title={Molecular dynamics simulations reveal the protective role of cholesterol in β-amyloid protein-induced membrane disruptions in neuronal membrane mimics.},
  author={Liming Qiu and Creighton Buie and Andrew Reay and Mark W. Vaughn and Kwan Hon Cheng},
  journal={The journal of physical chemistry. B},
  year={2011},
  volume={115 32},
  pages={9795-812}
}
Interactions of β-amyloid (Aβ) peptides with neuronal membranes have been associated with the pathogenesis of Alzheimer's disease (AD); however, the molecular details remain unclear. We used atomistic molecular dynamics (MD) simulations to study the interactions of Aβ(40) and Aβ(42) with model neuronal membranes. The differences between cholesterol-enriched and depleted lipid domains were investigated by the use of model phosphatidylcholine (PC) lipid bilayers with and without 40 mol… CONTINUE READING

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Monte Carlo: Concepts, Algorithms, and Applications

  • Fishman, GS
  • 1997

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