Molecular dynamics simulations of hydrophilic pores in lipid bilayers.

@article{Leontiadou2004MolecularDS,
  title={Molecular dynamics simulations of hydrophilic pores in lipid bilayers.},
  author={Hari Leontiadou and Alan E. Mark and Siewert J. Marrink},
  journal={Biophysical journal},
  year={2004},
  volume={86 4},
  pages={
          2156-64
        }
}
Hydrophilic pores are formed in peptide free lipid bilayers under mechanical stress. It has been proposed that the transport of ionic species across such membranes is largely determined by the existence of such meta-stable hydrophilic pores. To study the properties of these structures and understand the mechanism by which pore expansion leads to membrane rupture, a series of molecular dynamics simulations of a dipalmitoylphosphatidylcholine (DPPC) bilayer have been conducted. The system was… CONTINUE READING

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