Molecular dynamics simulations indicate a possible role of parallel beta-helices in seeded aggregation of poly-Gln.

@article{Stork2005MolecularDS,
  title={Molecular dynamics simulations indicate a possible role of parallel beta-helices in seeded aggregation of poly-Gln.},
  author={Martina Stork and Armin Giese and Hans A. Kretzschmar and Paul Tavan},
  journal={Biophysical journal},
  year={2005},
  volume={88 4},
  pages={
          2442-51
        }
}
The molecular structures of amyloid fibers characterizing neurodegenerative diseases such as Huntington's or transmissible spongiform encephalopathies are unknown. Recently, x-ray diffraction patterns of poly-Gln fibers and electron microscopy images of two-dimensional crystals formed from building blocks of prion rods have suggested that the corresponding amyloid fibers are generated by the aggregation of parallel beta-helices. To explore this intriguing concept, we study the stability of… CONTINUE READING
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