Molecular dynamics simulations and principal component analysis on human laforin mutation W32G and W32G/K87A.

Abstract

Mutations in human laforin lead to an autosomal neurodegenerative disorder Lafora disease. In N-terminal carbohydrate binding domain of laforin, two mutations W32G and K87A are reported as highly disease causing laforin mutants. Experimental studies reported that mutations are responsible for the abolishment of glycogen binding which is a critical function… (More)
DOI: 10.1007/s10930-014-9561-2

Topics

Cite this paper

@article{Srikumar2014MolecularDS, title={Molecular dynamics simulations and principal component analysis on human laforin mutation W32G and W32G/K87A.}, author={P. S. Srikumar and Karunakaran Rohini and Perumbilavil Kaithamanakallam Rajesh}, journal={The protein journal}, year={2014}, volume={33 3}, pages={289-95} }