Molecular dynamics simulation of shear- and stretch-induced dissociation of P-selectin/PSGL-1 complex.

Abstract

By mediating the tethering and rolling of leukocytes on vascular surfaces, the interactions between P-selectin and the P-selectin glycoprotein ligand 1 (PSGL-1) play crucial roles during inflammation cascade. Tensile stretch produced by rolling leukocytes and shear stress exerted by blood flow constitute the two types of mechanical forces that act on the P… (More)
DOI: 10.1016/j.bpj.2011.11.4002

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Cite this paper

@article{Kang2012MolecularDS, title={Molecular dynamics simulation of shear- and stretch-induced dissociation of P-selectin/PSGL-1 complex.}, author={Yingyong Kang and Shouqin L{\"u} and Peng Ren and Bo Huo and Mian Long}, journal={Biophysical journal}, year={2012}, volume={102 1}, pages={112-20} }