Molecular dynamics of the sodium channel pore vary with gating: interactions between P-segment motions and inactivation.

@article{Benitah1999MolecularDO,
  title={Molecular dynamics of the sodium channel pore vary with gating: interactions between P-segment motions and inactivation.},
  author={Jean Pierre Benitah and Z Chen and Jeffrey R. Balser and Gordon F. Tomaselli and Eduardo Marb{\'a}n},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 5},
  pages={1577-85}
}
Disulfide trapping studies have revealed that the pore-lining (P) segments of voltage-dependent sodium channels undergo sizable motions on a subsecond time scale. Such motions of the pore may be necessary for selective ion translocation. Although traditionally viewed as separable properties, gating and permeation are now known to interact extensively in various classes of channels. We have investigated the interaction of pore motions and voltage-dependent gating in micro1 sodium channels… CONTINUE READING

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