Molecular dynamics of synthetic leucine-serine ion channels in a phospholipid membrane.

@article{Randa1999MolecularDO,
  title={Molecular dynamics of synthetic leucine-serine ion channels in a phospholipid membrane.},
  author={H S Randa and Lucy R. Forrest and Gregory A. Voth and Mark S. P. Sansom},
  journal={Biophysical journal},
  year={1999},
  volume={77 5},
  pages={2400-10}
}
Molecular dynamics calculations were carried out on models of two synthetic leucine-serine ion channels: a tetrameric bundle with sequence (LSLLLSL)(3)NH(2) and a hexameric bundle with sequence (LSSLLSL)(3)NH(2). Each protein bundle is inserted in a palmitoyloleoylphosphatidylcholine bilayer membrane and solvated by simple point charge water molecules inside the pore and at both mouths. Both systems appear to be stable in the absence of an electric field during the 4 ns of molecular dynamics… CONTINUE READING

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