Molecular dynamics of solid-state lysozyme as affected by glycerol and water: a neutron scattering study.

@article{Tsai2000MolecularDO,
  title={Molecular dynamics of solid-state lysozyme as affected by glycerol and water: a neutron scattering study.},
  author={A M Tsai and Dan A. Neumann and L N Bell},
  journal={Biophysical journal},
  year={2000},
  volume={79 5},
  pages={2728-32}
}
Glycerol has been shown to lower the heat denaturation temperature (T(m)) of dehydrated lysozyme while elevating the T(m) of hydrated lysozyme (. J. Pharm. Sci. 84:707-712). Here, we report an in situ elastic neutron scattering study of the effect of glycerol and hydration on the internal dynamics of lysozyme powder. Anharmonic motions associated with structural relaxation processes were not detected for dehydrated lysozyme in the temperature range of 40 to 450K. Dehydrated lysozyme was found… CONTINUE READING

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