Molecular dynamics of point mutated I-A(k) molecules expressed on lymphocytes.

@article{Munnelly2001MolecularDO,
  title={Molecular dynamics of point mutated I-A(k) molecules expressed on lymphocytes.},
  author={Heidi Munnelly and Colin J. Brady and Guy M. Hagen and Regina D. Horvat and William. F. Wade and Deborah A. Roess and B. George Barisas},
  journal={Immunology letters},
  year={2001},
  volume={77 3},
  pages={187-96}
}
We have recently reported the lateral and rotational diffusion parameters for I-A(k) molecules expressing various cytoplasmic truncations (Int. Immunol. 12 (2000) 1319). We now describe the membrane dynamics of I-A(k) with various mutations in the presumed contact region between alphabeta-heterodimers in an (alphabeta)2 dimer of dimers structure. Such mutations are known to strongly affect the antigen presentation ability of these molecules (Int. Immunol. 10 (1998) 1237-1249) but cause… CONTINUE READING