Molecular dynamics of histone H1.

  title={Molecular dynamics of histone H1.},
  author={Thomas W. Flanagan and David T. Brown},
  journal={Biochimica et biophysica acta},
  volume={1859 3},
The H1 or linker histones bind dynamically to chromatin in living cells via a process that involves transient association with the nucleosome near the DNA entry/exit site followed by dissociation, translocation to a new location, and rebinding. The mean residency time of H1 on any given nucleosome is about a minute, which is much shorter than that of most core histones but considerably longer than that of most other chromatin-binding proteins, including transcription factors. Here we review… CONTINUE READING