Molecular dynamics of estrogen-related receptors and their regulatory proteins: roles in transcriptional control for endocrine and metabolic signaling

  title={Molecular dynamics of estrogen-related receptors and their regulatory proteins: roles in transcriptional control for endocrine and metabolic signaling},
  author={Takashi Tanida},
  journal={Anatomical Science International},
  • Takashi Tanida
  • Published 5 October 2021
  • Biology
  • Anatomical Science International
Estrogen-related receptor (ERR) is a member of the nuclear receptor (NR) superfamily and has three subtypes α, β, and γ. Despite their strong homology with estrogen receptor (ER) α, ERRs cannot accommodate endogenous hormones. However, they are able to regulate gene expression without ligand binding. ERRα and ERRγ orchestrate the expression of genes involved in bioenergetic pathways, while ERRβ controls placental development and stem cell maintenance. Evidence from recent studies, including… 


Subcellular dynamics of estrogen-related receptors involved in transrepression through interactions with scaffold attachment factor B1.
It is reported that ERRs show subcellular kinetic changes in response to diethylstilbestrol (DES), a synthetic estrogen that represses the transactivity of all three ERR subtypes, using live-cell imaging with fluorescent protein labeling and ligand-dependent cluster formation of ERRs in the nucleus that is closely associated with SAFB1-mediated transrepression.
Transcriptional control of energy homeostasis by the estrogen-related receptors.
Recent and rapid advances in understanding the functions of the ERRs in regulating bioenergetic pathways are reviewed, with an emphasis on their roles in the specification of energetic properties required for cell- and tissue-specific functions.
Estrogen-related Receptor β Reduces the Subnuclear Mobility of Estrogen Receptor α and Suppresses Estrogen-dependent Cellular Function*
Results provide strong evidence for a suppressive effect of ERRβ on estrogen signaling through reduction of the intranuclear mobility of ERα and suggest a unique inhibitory role for ERR β in estrogen-dependent cellular function such as cancer cell proliferation.
Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors.
Results demonstrate that estrogen-inducible genes such as pS2 can be ERR targets and suggest that pharmacological modulation of ERRalpha activity may have therapeutic value in the treatment of breast cancer.
Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling
Recent research advancement in understanding the roles of ERs and ERRs in the brain is reviewed, with particular emphasis on ERRs, and possible cross-talk between ERs-related receptors and ERs in behavioral and physiological regulations is discussed.
Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult.
The existence in humans of a third member of this subfamily of receptors, termed ERRgamma, which is highly expressed in a number of diverse fetal and adult tissues including brain, kidney, pancreas, and placenta, is demonstrated.
Estrogen-related Receptor α1 Actively Antagonizes Estrogen Receptor-regulated Transcription in MCF-7 Mammary Cells*
It is hypothesized that ERRα1 can play a critical role in the etiology of some breast cancers, thereby providing a novel therapeutic target in their treatment.
Estrogen-related Receptor γ (ERRγ) Is a Novel Transcriptional Regulator of Phosphatidic Acid Phosphatase, LIPIN1, and Inhibits Hepatic Insulin Signaling*
It is reported that nuclear estrogen-related receptor (ERR) γ is a novel transcriptional regulator of LIPIN1 and the selective control of ERRγ transcriptional activity by its specific inverse agonist could provide a novel therapeutic approach to the amelioration of impaired hepatic insulin signaling induced by LipIN1-mediated PKCϵ activation.
The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene
Results demonstrate that ERR alpha can control the expression of MCAD through the NRRE-1 and thus may play an important role in regulating cellular energy balance in vivo.