Molecular dynamics investigations on the effect of D amino acid substitution in a triple-helix structure and the stability of collagen.

@article{Punitha2009MolecularDI,
  title={Molecular dynamics investigations on the effect of D amino acid substitution in a triple-helix structure and the stability of collagen.},
  author={V. Punitha V. Punitha and Stevan S Raman and Ramakrishnan Parthasarathi and Vijaya Subramanian and Jonnalagadda Raghava Rao and Balachandran Unni Nair and Thirumalachari Ramasami},
  journal={The journal of physical chemistry. B},
  year={2009},
  volume={113 26},
  pages={
          8983-92
        }
}
Studies on the structure and stability of peptides and proteins during l-->d configurational change are certainly important for the designing of peptides with new biological activity and protein engineering. The l-->d amino acid (d AA) changes have been observed in aged proteins such as collagen. Hence, in this study, an attempt has been made to explore the effect of the replacement of l amino acid (l AA) in the model collagen-like peptides with d AA and the origin of structural stability… CONTINUE READING
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