Molecular dynamics analysis of HIV-1 matrix protein: clarifying differences between crystallographic and solution structures.

@article{Verli2007MolecularDA,
  title={Molecular dynamics analysis of HIV-1 matrix protein: clarifying differences between crystallographic and solution structures.},
  author={Hugo Verli and Alexandre Calazans and Rodrigo Brindeiro and Amilcar Tanuri and J. A. Guimar{\~a}es},
  journal={Journal of molecular graphics & modelling},
  year={2007},
  volume={26 1},
  pages={62-8}
}
One of the main structural features of the mature HIV-1 virion is the matrix protein (p17). This partially globular protein presents four helixes centrally organized and a fifth one, H5, projecting away from the packed bundle of helixes. Comparison between solution and crystallographic data of p17 indicates a 6 A displacement of a short 3(10) helix and a partial unfolding of H5 in solution related to crystal. While the behavior of the 3(10) helix has been previously addressed to virion assembly… CONTINUE READING

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