Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

@article{Khan2014MolecularDA,
  title={Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease},
  author={U. A. Khan and Li Liu and Frank Anthony Provenzano and Diego E Berman and Caterina P. Profaci and Richard Sloan and Richard Mayeux and Karen E Duff and Scott A. Small},
  journal={Nature Neuroscience},
  year={2014},
  volume={17},
  pages={304-311}
}
The entorhinal cortex has been implicated in the early stages of Alzheimer's disease, which is characterized by changes in the tau protein and in the cleaved fragments of the amyloid precursor protein (APP). We used a high-resolution functional magnetic resonance imaging (fMRI) variant that can map metabolic defects in patients and mouse models to address basic questions about entorhinal cortex pathophysiology. The entorhinal cortex is divided into functionally distinct regions, the medial… CONTINUE READING
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