Molecular dosimetry of DNA and hemoglobin adducts in mice and rats exposed to ethylene oxide.

  title={Molecular dosimetry of DNA and hemoglobin adducts in mice and rats exposed to ethylene oxide.},
  author={Vernon E. Walker and Timothy R. Fennell and Patricia B. Upton and John P MacNeela and James A. Swenberg},
  journal={Environmental Health Perspectives},
  pages={11 - 17}
Experiments involving ethylene oxide (ETO) have been used to support the concept of using adducts in hemoglobin as a surrogate for DNA adducts in target tissues. The relationship between repeated exposures to ETO and the formation of N-(2-hydroxyethyl)valine (HEtVal) in hemoglobin and 7-(2-hydroxyethyl)guanine (7-HEG) in DNA was investigated in male rats and mice exposed by inhalation to 0, 3, 10, 33, or 100 ppm ETO for 6 hr/day for 4 weeks, or exposed to 100 ppm (mice) or 300 ppm (rats) for 1… CONTINUE READING


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