Molecular docking study of a tocotrienol and P-glycoprotein

Abstract

Multidrug resistance is a major challenge in cancer chemotherapy and is often linked to the overexpression of P-glycoprotein (P-gp). P-gp acts as an energy-requiring efflux pump for various types of natural products and compounds including chemotherapeutic drugs. In this study, tocotrienol, a member of the vitamin E family is studied to explore its… (More)

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