# Molecular docking programs successfully predict the binding of a β-lactamase inhibitory protein to TEM-1 β-lactamase

@article{Strynadka1996MolecularDP,
title={Molecular docking programs successfully predict the binding of a $\beta$-lactamase inhibitory protein to TEM-1 $\beta$-lactamase},
author={N. Strynadka and M. Eisenstein and E. Katchalski‐Katzir and B. Shoichet and I. Kuntz and R. Abagyan and M. Totrov and J. Janin and J. Cherfils and F. Zimmerman and A. Olson and B. Duncan and M. Rao and R. Jackson and M. Sternberg and M. James},
journal={Nature Structural Biology},
year={1996},
volume={3},
pages={233-239}
}
Crystallization of the 1:1 molecular complex between the β-lactamase TEM-1 and the β-lactamase inhibitory protein BLIP has provided an opportunity to put a stringent test on current protein-docking algorithms. Prior to the successful determination of the structure of the complex, nine laboratory groups were given the refined atomic coordinates of each of the native molecules. Other than the fact that BLIP is an effective inhibitor of a number of β-lactamase enzymes (KI for TEM-1∼100 pM) no… Expand
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