Molecular docking approach on the Topoisomerase I inhibitors series included in the NCI anti-cancer agents mechanism database.

@article{Lauria2007MolecularDA,
  title={Molecular docking approach on the Topoisomerase I inhibitors series included in the NCI anti-cancer agents mechanism database.},
  author={Antonino Lauria and Mario Ippolito and Anna Maria Almerico},
  journal={Journal of molecular modeling},
  year={2007},
  volume={13 3},
  pages={393-400}
}
Topoisomerase I (Top1) is an essential enzyme participating to all those processes associated with separation of DNA strands. It manages superhelical tensions through the transient breakage of one strand of duplex DNA, followed by the unwinding of supercoiled DNA. Camptothecins, a class of alkaloids extracted from the wood of a Chinese tree, were found to be potent inhibitors of Topoisomerase I. The National Cancer Institute (NCI) Anti-cancer Agents Mechanism Database contains several… CONTINUE READING