Molecular docking and in silico studies on analogues of 2-methylheptyl isonicotinate with DHDPS enzyme of Mycobacterium tuberculosis

@article{Singh2013MolecularDA,
  title={Molecular docking and in silico studies on analogues of 2-methylheptyl isonicotinate with DHDPS enzyme of Mycobacterium tuberculosis},
  author={S. P. Singh and B. K. Konwar and R. Bezbaruah and T. Bora},
  journal={Medicinal Chemistry Research},
  year={2013},
  volume={22},
  pages={4755-4765}
}
Mycobacterium tuberculosis and other strains of mycobacteria cause tuberculosis which has infected one-third of the world’s population. Moreover, there has been increase in multidrug-resistant strains which spotlights the need for a new anti-tuberculosis drug. The cell wall of mycobacteria is characterised by high diaminopimelic acid (DAP) content—an intermediate of the (S)-lysine biosynthetic pathway and dihydrodipicolinate synthase (DHDPS) enzyme catalyses the first unique reaction of this… Expand

References

SHOWING 1-10 OF 38 REFERENCES
Virtual Screening of potential drug-like inhibitors against Lysine/DAP pathway of Mycobacterium tuberculosis
Synthesis, absolute stereochemistry and molecular design of the new antifungal and antibacterial antibiotic produced by Streptomyces sp.201.
Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis.
Escherichia coli dihydrodipicolinate synthase. Identification of the active site and crystallization.
Bacterial diaminopimelate metabolism as a target for antibiotic design.
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