Molecular docking and P-glycoprotein inhibitory activity of Flavonoids

@article{Daddam2012MolecularDA,
  title={Molecular docking and P-glycoprotein inhibitory activity of Flavonoids},
  author={Jayasimha Rayalu Daddam and Muralidhara Rao Dowlathabad and Seshapani Panthangi and Pramodakumari Jasti},
  journal={Interdisciplinary Sciences: Computational Life Sciences},
  year={2012},
  volume={6},
  pages={167-175}
}
Flavonoids are the most common group of phenolic compounds that have anti-carcinogenic properties and are the constituents of fruits, vegetables and plant derived beverages. In the present study, Flavonoids were docked to three-dimensional structure of P-glycoprotein which plays an important role in multi drug resistance. A three-dimensional homology model of human P-glycoprotein was built, based on the crystal structure of the 3G5U (Chain A; Structure of a bacterial multidrug ABC transporter… CONTINUE READING

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