Molecular docking and 3D QSAR studies of substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as insulin-like growth factor-1 receptor (IGF1R) inhibitors

Insulin-like growth factor-1 receptor (IGF1R) is one of receptor tyrosine kinase that plays a significant role in cancer and has been pursued as drug target for cancer therapy. Molecular docking and comparative molecular field analysis (CoMFA) studies were carried out on the series of substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines IGF1R inhibitors. The… (More)