Molecular docking, 3D-QSAR and structural optimization on imidazo-pyridine derivatives dually targeting AT1 and PPARγ

Abstract

Telmisartan, a bifunctional agent of blood pressure lowering and glycemia reduction, was previously reported to antagonize angiotensin II type 1 (AT1) receptor and partially activate peroxisome proliferator-activated receptor γ (PPARγ) simultaneously. Through the modification to telmisartan, researchers designed and obtained imidazo-\pyridine derivatives… (More)
DOI: 10.18632/oncotarget.15778

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Cite this paper

@inproceedings{Zhang2017MolecularD3, title={Molecular docking, 3D-QSAR and structural optimization on imidazo-pyridine derivatives dually targeting AT1 and PPARγ}, author={Jun Zhang and Qing-qing Hao and Xin Liu and Zhi Min Jing and Wen-qing Jia and Shu-Qing Wang and Wei-ren Xu and Xian-Chao Cheng and Run-ling Wang}, booktitle={Oncotarget}, year={2017} }