Molecular diversity through RNA editing: a balancing act.

  title={Molecular diversity through RNA editing: a balancing act.},
  author={Sanaz Farajollahi and Stefan Maas},
  journal={Trends in genetics : TIG},
  volume={26 5},
RNA editing by adenosine deamination fuels the generation of RNA and protein diversity in eukaryotes, particularly in higher organisms. This includes the recoding of translated exons, widespread editing of retrotransposon-derived repeat elements and sequence modification of microRNA (miRNA) transcripts. Such changes can bring about specific amino acid substitutions, alternative splicing and changes in gene expression levels. Although the overall prevalence of adenosine-to-inosine (A-to-I… CONTINUE READING