Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes.

@article{PerezReyes1990MolecularDO,
  title={Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes.},
  author={Edward Perez-Reyes and Xiquan Wei and Antonio Castellano and Lutz Birnbaumer},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 33},
  pages={20430-6}
}
The diversity of L-type calcium channels was probed using the polymerase chain reaction and primers based on regions conserved in the L-type skeletal muscle (CaCh 1) and cardiac calcium channels (CaCh 2). Related sequences were amplified from human heart, hamster heart, rabbit heart, mouse ovary, mouse BC3H1 cells, and hamster insulin-secreting (HIT) cells. Sequencing of various clones revealed the presence of alternate splicing in gene products coding for CaCh 1, CaCh 2, and a related calcium… CONTINUE READING

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