Molecular diversity and population structure at the Cytochrome P450 3A5 gene in Africa

  title={Molecular diversity and population structure at the Cytochrome P450 3A5 gene in Africa},
  author={Ripudaman K Bains and Mirna Kovacevic and Christopher Andrew Plaster and Ayele Tarekegn and Endashaw J. Bekele and Neil N Bradman and Mark G. Thomas},
  booktitle={BMC Genetics},
Cytochrome P450 3A5 (CYP3A5) is an enzyme involved in the metabolism of many therapeutic drugs. CYP3A5 expression levels vary between individuals and populations, and this contributes to adverse clinical outcomes. Variable expression is largely attributed to four alleles, CYP3A5*1 (expresser allele); CYP3A5*3 (rs776746), CYP3A5*6 (rs10264272) and CYP3A5*7 (rs41303343) (low/non-expresser alleles). Little is known about CYP3A5 variability in Africa, a region with considerable genetic diversity… CONTINUE READING
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