Molecular diversity and population structure at the Cytochrome P450 3A5 gene in Africa

@inproceedings{Bains2013MolecularDA,
  title={Molecular diversity and population structure at the Cytochrome P450 3A5 gene in Africa},
  author={Ripudaman K Bains and Mirna Kovacevic and Christopher Andrew Plaster and Ayele Tarekegn and Endashaw J. Bekele and Neil N Bradman and Mark G. Thomas},
  booktitle={BMC Genetics},
  year={2013}
}
Cytochrome P450 3A5 (CYP3A5) is an enzyme involved in the metabolism of many therapeutic drugs. CYP3A5 expression levels vary between individuals and populations, and this contributes to adverse clinical outcomes. Variable expression is largely attributed to four alleles, CYP3A5*1 (expresser allele); CYP3A5*3 (rs776746), CYP3A5*6 (rs10264272) and CYP3A5*7 (rs41303343) (low/non-expresser alleles). Little is known about CYP3A5 variability in Africa, a region with considerable genetic diversity… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 12 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

African variation at Cytochrome P450 genes

Evolution, medicine, and public health • 2013
View 8 Excerpts
Highly Influenced

Disease burden and the role of pharmacogenomics in African populations

Global health, epidemiology and genomics • 2017
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 85 references

CYP3A variation and the evolution of salt-sensitivity variants.

American journal of human genetics • 2004
View 10 Excerpts
Highly Influenced

Spatiotemporal distribution of aridity indices based on temperature and precipitation in the extra-Carpathian regions of Romania

A-E Croitoru, A Piticar, AM Imbroane, DC Burada
Theor Appl Climatol • 2012
View 3 Excerpts
Highly Influenced

Evolutionary medicine: its scope, interest and potential.

Proceedings. Biological sciences • 2012
View 1 Excerpt

Life Technologies promises $1,000 genome

Nature Biotechnology • 2012
View 1 Excerpt

Similar Papers

Loading similar papers…