Molecular diversity and evolution of the Siglec family of cell-surface lectins

@article{Angata2006MolecularDA,
  title={Molecular diversity and evolution of the Siglec family of cell-surface lectins},
  author={Takashi Angata},
  journal={Molecular Diversity},
  year={2006},
  volume={10},
  pages={555-566}
}
Sialic acids are a family of acidic sugars with a 9-carbon backbone, prominently expressed in animals of deuterostome lineage. Siglecs are the largest family of vertebrate endogenous receptors that recognize glycoconjugates containing sialic acids. Although a few Siglecs are well-conserved throughout vertebrate evolution and show similar binding preference regardless of the species of origin, most others, particularly the CD33-related subfamily of Siglecs, show marked inter-species differences… CONTINUE READING
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