Molecular divergence of two orthologous scorpion toxins affecting potassium channels.

@article{Gao2011MolecularDO,
  title={Molecular divergence of two orthologous scorpion toxins affecting potassium channels.},
  author={Bin Gao and Steve Peigneur and Julie Eleanor Dalziel and Jan Tytgat and Shunyi Zhu},
  journal={Comparative biochemistry and physiology. Part A, Molecular & integrative physiology},
  year={2011},
  volume={159 3},
  pages={
          313-21
        }
}
Alpha-KTxs are a diverse group of scorpion short-chain peptide toxins that affect animal potassium channels. We report the biochemical purification, gene cloning, and functional characterization of a new α-KTx named MeuTx3B, from venom of the scorpion Mesobuthus eupeus. MeuTx3B is an orthologue of BmTx3B/Martentoxin (α-KTx16 subfamily) from Mesobuthus martensii that differs by three amino acid substitutions. We found that despite their orthologous relationship, MeuTx3B and BmTx3B exhibit… CONTINUE READING
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