Molecular distribution of volume-regulated chloride channels (ClC-2 and ClC-3) in cardiac tissues.

@article{Britton2000MolecularDO,
  title={Molecular distribution of volume-regulated chloride channels (ClC-2 and ClC-3) in cardiac tissues.},
  author={Fiona C Britton and William J. Hatton and Charles F Rossow and Dana Duan and Joseph R. Hume and Brown Horowitz},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 5},
  pages={H2225-33}
}
The molecular identification of cardiac chloride channels has provided probes to investigate their distribution and abundance in heart. In this study, the molecular expression and distribution of volume-regulated chloride channels ClC-2 and ClC-3 in cardiac tissues were analyzed and quantified. Total RNA was isolated from atria and ventricles of several species (dog, guinea pig, and rat) and subjected to a quantitative RT-PCR strategy. ClC-2 and ClC-3 mRNA expression were calculated relative to… CONTINUE READING