Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells.

Abstract

Normal human epithelial cells in culture have generally shown a limited proliferative potential of approximately 10 to 40 population doublings before encountering a stress-associated senescence barrier (stasis) associated with elevated levels of cyclin-dependent kinase inhibitors p16 and/or p21. We now show that simple changes in medium composition can… (More)
DOI: 10.1158/0008-5472.CAN-09-0270

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@article{Garbe2009MolecularDB, title={Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells.}, author={James C. Garbe and Sanchita Bhattacharya and B. John Merchant and Ekaterina Bassett and Karen L Swisshelm and Heidi S. Feiler and Andrew J. Wyrobek and Martha R. Stampfer}, journal={Cancer research}, year={2009}, volume={69 19}, pages={7557-68} }