Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex.

@article{Prez2004MolecularDO,
  title={Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex.},
  author={Esther P{\'e}rez and Patricia Constant and Françoise Laval and Anne Lemassu and Marie-Antoinette Lan{\'e}elle and Mamadou Daff{\'e} and Christophe Guilhot},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 41},
  pages={42584-92}
}
A few mycobacterial species, most of which are pathogenic for humans, produce dimycocerosates of phthiocerol (DIM) and of glycosylated phenolphthiocerol, also called phenolglycolipid (PGL), two groups of molecules shown to be important virulence factors. The biosynthesis of these molecules is a very complex pathway that involves more than 15 enzymatic steps and has just begun to be elucidated. Most of the genes known to be involved in these pathways are clustered on the chromosome of M… CONTINUE READING

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