Molecular dissection of the human antibody response to the structural repeat epitope of Plasmodium falciparum sporozoite from a protected donor

@article{Chappel2004MolecularDO,
  title={Molecular dissection of the human antibody response to the structural repeat epitope of Plasmodium falciparum sporozoite from a protected donor},
  author={Jonathan A Chappel and William Oscar Rogers and Stephen L. Hoffman and Angray S. Kang},
  journal={Malaria Journal},
  year={2004},
  volume={3},
  pages={28 - 28}
}
The circumsporozoite surface protein is the primary target of human antibodies against Plasmodium falciparum sporozoites, these antibodies are predominantly directed to the major repetitive epitope (Asn-Pro-Asn-Ala)n, (NPNA)n. In individuals immunized by the bites of irradiated Anopheles mosquitoes carrying P. falciparum sporozoites in their salivary glands, the anti-repeat response dominates and is thought by many to play a role in protective immunity. The antibody repertoire from a protected… CONTINUE READING
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