Molecular dissection of the Y chromosome haplogroup E‐M78 (E3b1a): a posteriori evaluation of a microsatellite‐network‐based approach through six new biallelic markers

@article{Cruciani2006MolecularDO,
  title={Molecular dissection of the Y chromosome haplogroup E‐M78 (E3b1a): a posteriori evaluation of a microsatellite‐network‐based approach through six new biallelic markers},
  author={Fulvio Cruciani and Roberta La Fratta and Antonio Torroni and Peter A. Underhill and Rosaria Scozzari},
  journal={Human Mutation},
  year={2006},
  volume={27}
}
The human Y chromosome haplogroup E‐M78 (E3b1a) occurs commonly and is distributed in northern and eastern Africa, western Asia, and all of Europe. Previously, only two rarely observed internal biallelic markers (UEPs) were known within the E‐M78 clade. Here we report the identification of six novel UEPs that significantly refine the phylogeny of this haplogroup. Then, we evaluate the correspondence between the newly defined sub‐haplogroups and the E‐M78 haplotype clusters previously identified… 

Phylogeographic Refinement and Large Scale Genotyping of Human Y Chromosome Haplogroup E Provide New Insights into the Dispersal of Early Pastoralists in the African Continent

Time frames, phylogenetic structuring, and sociogeographic distribution of E-V1515 and its subclades are consistent with a multistep demic spread of pastoralism within north-eastern Africa and its subsequent diffusion to subequatorial areas.

Recurrent mutation in SNPs within Y chromosome E3b (E‐M215) haplogroup: A rebuttal

A novel polymorphic marker (V68) is introduced, potentially useful to investigate the issue of identity by state at multiple short tandem repeat loci between human Y chromosomes belonging to different E‐M35 sub‐haplogroups.

The Andalusian population from Huelva reveals a high diversification of Y-DNA paternal lineages from haplogroup E: Identifying human male movements within the Mediterranean space

The haplogroup E among Western Andalusians revealed a complex admixture of genetic markers from the Mediterranean space, with interesting signatures of populations from the Middle East and the Balkan Peninsula and a surprisingly low influence by Berber populations compared to other areas of the Iberian Peninsula.

Tracing past human male movements in northern/eastern Africa and western Eurasia: new clues from Y-chromosomal haplogroups E-M78 and J-M12.

The geographic and quantitative analyses of haplogroup and microsatellite diversity is strongly suggestive of a northeastern African origin of E-M78, with a corridor for bidirectional migrations between northeastern and eastern Africa and trans-Mediterranean migrations directly from northern Africa to Europe.

Introducing the Algerian Mitochondrial DNA and Y-Chromosome Profiles into the North African Landscape

A sample of 240 unrelated subjects from a northwest Algeria cosmopolitan population was analyzed using mtDNA sequences and Y-chromosome biallelic polymorphisms, focusing on the fine dissection of haplogroups E and R, which are the most prevalent in North Africa and Europe respectively.

Y-chromosome diversity characterizes the Gulf of Oman

High-resolution Y-chromosome analysis of males from the United Arab Emirates, Qatar and Yemen revealed high diversity in their Y-haplogroup substructure possibly a result of gene flow along the coastal crescent-shaped corridor of the Gulf of Oman facilitating human dispersals.

Y-chromosome polymorphisms in southern Arabia

With the exception of Yemen, southern Arabia displays high diversity in its Y-haplogroup substructure and share similarities with populations along the eastern coast of the Gulf of Oman, possibly serving as a coastal corridor for migrations.

Divergent patrilineal signals in three Roma populations.

Y-chromosome distributions in three Roma collections residing in Belgrade, Vojvodina and Kosovo are reported for the first time and illustrate that the most notable difference among the three Roma populations is in their opposing distributions of haplogroups H and E.

Extended Y chromosome haplotypes resolve multiple and unique lineages of the Jewish priesthood

The hypothesis of a common origin of the CMH in the Near East well before the dispersion of the Jewish people into separate communities is supported and indicates that the majority of contemporary Jewish priests descend from a limited number of paternal lineages.

References

SHOWING 1-10 OF 37 REFERENCES

Phylogeographic analysis of haplogroup E3b (E-M215) y chromosomes reveals multiple migratory events within and out of Africa.

The present study shows that earlier work based on fewer Y-chromosome markers led to rather simple historical interpretations and highlights the fact that many population-genetic analyses are not robust to a poorly resolved phylogeny and reveals signatures of several distinct processes of migrations and/or recurrent gene flow that occurred in Africa and western Eurasia over the past 25000 years.

Origin, diffusion, and differentiation of Y-chromosome haplogroups E and J: inferences on the neolithization of Europe and later migratory events in the Mediterranean area.

The phylogeography of Y-chromosome haplogroups E and J was investigated in >2400 subjects from 29 populations, mainly from Europe and the Mediterranean area but also from Africa and Asia, revealing spatial patterns that are consistent with a Levantine/Anatolian dispersal route to southeastern Europe.

High frequencies of Y chromosome lineages characterized by E3b1, DYS19-11, DYS392-12 in Somali males

The data suggest that the male Somali population is a branch of the East African population – closely related to the Oromos in Ethiopia and North Kenya – with predominant E3b1 cluster γ lineages that were introduced into the Somali population 4000–5000 years ago, and that the Somali male population has approximately 15% Y chromosomes from Eurasia and approximately 5% from sub-Saharan Africa.

Y chromosomal haplogroup J as a signature of the post-neolithic colonization of Europe

Dating estimates confirmed the presence of a major population structuring at the time of spread of haplogroup J in Europe and a punctuation in the peopling of this continent in the post-Neolithic, compatible with the expansion of the Greek world.

Excavating Y-chromosome haplotype strata in Anatolia

This comprehensive characterization of Y-chromosome heritage addresses many multifaceted aspects of Anatolian prehistory, including: the most frequent haplogroup, J, splits into two sub-clades, one of which (J2) shows decreasing variances with increasing latitude, compatible with a northward expansion.

The molecular dissection of mtDNA haplogroup H confirms that the Franco-Cantabrian glacial refuge was a major source for the European gene pool.

Findings have major implications for the origin of Europeans, since they attest that the Franco-Cantabrian refuge area was indeed the source of late-glacial expansions of hunter-gatherers that repopulated much of Central and Northern Europe from ~15,000 years ago.

A multistep process for the dispersal of a Y chromosomal lineage in the Mediterranean area.

A microsatellite-defined Y-chromosomal lineage identified by us and reported in previous studies, whose geographic distribution and antiquity appear to be compatible with the Neolithic spread of farmers suggests that its spread was associated to a population expansion, with a high rate of male gene flow in the Turkish-Greek area.

Signature of recent historical events in the European Y-chromosomal STR haplotype distribution

It is concluded that Y-STRs may be capable of resolving male genealogies to an unparalleled degree and could therefore provide a useful means to study local population structure and recent demographic history.

A predominantly neolithic origin for Y-chromosomal DNA variation in North Africa.

The Neolithic transition in this part of the world was accompanied by demic diffusion of Afro-Asiatic-speaking pastoralists from the Middle East, and it is suggested that the North African pattern of Y-chromosomal variation is largely of Neolithic origin.