Molecular dissection of the Prader-Willi/Angelman syndrome region (15q11-13) by YAC cloning and FISH analysis.

@article{Kuwano1992MolecularDO,
  title={Molecular dissection of the Prader-Willi/Angelman syndrome region (15q11-13) by YAC cloning and FISH analysis.},
  author={Akira Kuwano and Apiwat Mutirangura and B{\"a}rbel Dittrich and Karin Buiting and Bernhard Horsthemke and Shinji Saitoh and Norio Niikawa and Susan A. Ledbetter and Frank Greenberg and Alan Craig Chinault},
  journal={Human molecular genetics},
  year={1992},
  volume={1 6},
  pages={417-25}
}
Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are distinct mental retardation disorders associated with deletions of proximal 15q (q11-q13) of different parental origin. Yeast artificial chromosome (YAC) clones were isolated for 9 previously mapped DNA probes from this region, and for one newly derived marker, LS6-1 (D15S113). A YAC contig of 1-1.5 Mb encompassing four markers (ML34, IR4-3R, PW71, and TD189-1) was constructed. Multi-color fluorescence in situ hybridization (FISH… CONTINUE READING

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Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Molecular dissection of the Prader - Willi / Angelman syndrome region ( 15q11 - 13 ) by YAC cloning and FISH analysis .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Molecular dissection of the Prader - Willi / Angelman syndrome region ( 15q11 - 13 ) by YAC cloning and FISH analysis .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Prader - Willi syndrome ( PWS ) and Angelman syndrome ( AS ) are distinct mental retardation disorders associated with deletions of proximal 15q ( q11-q13 ) of different parental origin .
Yeast artificial chromosome ( YAC ) clones were isolated for 9 previously mapped DNA probes from this region , and for one newly derived marker , LS6 - 1 ( D15S113 ) .
Yeast artificial chromosome ( YAC ) clones were isolated for 9 previously mapped DNA probes from this region , and for one newly derived marker , LS6 - 1 ( D15S113 ) .
Yeast artificial chromosome ( YAC ) clones were isolated for 9 previously mapped DNA probes from this region , and for one newly derived marker , LS6 - 1 ( D15S113 ) .
Yeast artificial chromosome ( YAC ) clones were isolated for 9 previously mapped DNA probes from this region , and for one newly derived marker , LS6 - 1 ( D15S113 ) .
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