Molecular dissection of t(11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants.

Abstract

The majority of translocations that involve the long arms of chromosomes 11 and 17 in acute myeloid leukemia appear identical on the cytogenetic level. Nevertheless, they are diverse on the molecular level. At present, two genes are known in 11q23 and four in 17q12-25 that generate five distinct fusion genes: MLL-MLLT6/AF17, MLL-LASP1, MLL-ACACA or MLL… (More)

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@article{Strehl2006MolecularDO, title={Molecular dissection of t(11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants.}, author={Sabine Strehl and Margit Koenig and Claus Meyer and Bjoern Schneider and Jochen Harbott and U. J{\"a}ger and Anne R M von Bergh and Ivan F. Loncarevic and Marie Jarosova and Helmut H. Schmidt and Steven D P Moore and Rolf Marschalek and Oskar Arthur Haas}, journal={Genes, chromosomes & cancer}, year={2006}, volume={45 11}, pages={1041-9} }