Molecular dissection of formation of senescence-associated heterochromatin foci.

@article{Zhang2007MolecularDO,
  title={Molecular dissection of formation of senescence-associated heterochromatin foci.},
  author={Rugang Zhang and Wei Chen and Peter David Adams},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 6},
  pages={
          2343-58
        }
}
Senescence is characterized by an irreversible cell proliferation arrest. Specialized domains of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF), are thought to contribute to the irreversible cell cycle exit in many senescent cells by repressing the expression of proliferation-promoting genes such as cyclin A. SAHF contain known heterochromatin-forming proteins, such as heterochromatin protein 1 (HP1) and the histone H2A variant macroH2A, and other… CONTINUE READING

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